There are over 400 types of compounds present in ginger.

There is enough evidence to prove that ginger possesses multiple biological activities, especially antioxidant and anti-inflammatory capacities.

Ginger extract works via the 6-Shogaol for Nrf2 pathwaysP21 and p-P13k.

Ginger inhibits lipid peroxidation through its antioxidant effect. 6-gingerol increases Beclin1 expression to promote autophagy in endothelial cells, and inhibits PI3K/AKT/mTOR pathway signaling without affecting cell cycle.

It has analgesic and anti-inflammatory effect by inhibiting COX2 and LOX pathways, therefore preventing arachidonic acid metabolism.

The effect of ginger has been shown to be similar to the NSAIDs family, however, it does not have a negative effect on the stomach mucosa.

Ginger does not act as an inhibitor of COX1, as it is specific to COX2.

Also has anti-microbial, anti-oxidant, anti-allergic activities as well as helping to prevent cancer among numerous other medical conditions.

Stimulates the expression of antioxidant enzymes & reduces the generation of ROS & lipid peroxidation.

Several ginger bioactive compounds such as 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol, exhibit antioxidant activity. 6-shogaol = highest activity. 

The oxidative stress is mediated by interleukin-1B (IL-1B). Ginger contains a vast amount of antioxidant compounds, nearly 40.